Oxidative DNA dam age
نویسندگان
چکیده
Sev eral char ac ter is tics of the ba sic types of ox i da tive DNA dam age are ana lysed in the pres ent work. They are as fol lows: base and sugar mod i fi ca tions le sions, sin gle-strand and dou ble-strand breaks, apurinic/apyrimidinic sites and DNA-pro teins cross-links. The chem i cal struc ture of the most in ves ti gated types of ox i da tive DNA dam age is shown. The most com mon genotoxic agents (re ac tive ox y gen spe cies, free rad i cals, alkylating agents) are also dis cussed. The meth ods of iden ti fi ca tion and mea sure ment of ox i da tive DNA dam age are con sid ered.
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تاریخ انتشار 2007